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应用PCR方法对22例缓解后儿童急淋白血病的MRD进行检测,并进行了5年临床随访。受检者中MRD阳性5例,其中2例为已终止化疗的患儿。阳性者于检测后的2～42个月时伴骨髓复发;阴性者中有2例于检测后第36、42个月时伴骨髓复发,其余皆已终止化疗长期存活。结果表明,利用此方法有助于早期预测ALL的复发,对终止化疗的ALL患儿也有必要定期进行MRD的检测。
The MRD of 22 children with acute leukemia after remission were detected by PCR and were followed up for 5 years. The subjects were MRD-positive in 5 cases, of which 2 cases had been terminated chemotherapy in children. Positive patients had bone marrow recurrence 2 ~ 42 months after the test, while 2 of the negative patients had bone marrow recurrence 36 and 42 months after the test. The remaining patients all had long-term survival after the termination of chemotherapy. The results show that the use of this method is helpful to predict the recurrence of ALL in the early stage, and it is also necessary to carry out MRD on a regular basis in patients with ALL who have stopped chemotherapy.