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使用从天然牡蛎中以酶提取法得到的牡蛎肉提取剂(以下称TOE),研究了活体内投与TOE的影响。①急性毒性试验:使用6周龄的Wistar雄性大鼠(体重256～300g)(编者注:原文误为3003g)6只。将粉末状干燥TOE2.0g溶解于3ml自来水中,用胃管经口1次投与。投与前和投与24小时后从锁骨下静脉采血,测定末梢血、肝肾功能、脂质、金属成分,研究其数值变化。②亚急性毒性试验:使用7周龄Wistar雄性大鼠(体重310～330g)10只。将TOE末1.0g溶解于3ml自来水,1日1次,5只用胃管经口投与10日(投药组),另5只仅投与自来水(对照组)。投与11日后锁骨下静脉采血,测
Using the oyster meat extract (hereinafter referred to as TOE) obtained by the enzyme extraction method from natural oysters, the effect of TOE administered in vivo was studied. 1 Acute toxicity test: Six 6-week-old Wistar male rats (body weight: 256 to 300 g) (editor’s note: textual error: 3003 g) were used. The dry powdered TOE 2.0 g was dissolved in 3 ml of tap water and administered via the stomach tube once. Blood was collected from the subclavian vein 24 hours before and 24 hours after the administration. Peripheral blood, liver and kidney function, lipids, and metal components were measured and their numerical changes were examined. 2 Subacute toxicity test: Ten 7-week-old Wistar male rats (310-330 g in body weight) were used. Dissolve 1.0 g of TOE in 3 ml of tap water once a day. Five rats were orally administered 10 days (administration group) and the other 5 were administered only tap water (control group). After 11 days of administration, blood was collected from the subclavian vein and measured.