(+)-生物素是维生素B家族中的一员,自发现以来对其全合成的报道层出不穷.在最近十几年中,数十条新的合成路线和改进方法陆续报道.(+)-生物素全合成策略主要分为两类:对映选择性合成和立体专一性合成.前一策略中,通过各种反应方法对经典的Hoffmann-La-Roche-硫内酯法进行改进和完善,其中不对称催化合成的方法已成功应用于工业化生产;在后一策略中,以L-半胱氨酸为起始原料的合成途径得到了较大发展,正越来越具有工业意义. (+) - Biotin, a member of the vitamin B family, has seen an endless stream of reports on its total synthesis since its discovery. Over the last decade, dozens of new synthetic routes and improvements have been reported. There are two main types of biotin synthesis strategies: enantioselective synthesis and stereospecific synthesis.In the previous strategy, the classical Hoffmann-La-Roche-thiolactone method was improved and refined by various reaction methods , Of which asymmetric catalytic synthesis method has been successfully applied to industrial production; in the latter strategy, to L-cysteine ​​as a starting material for the synthesis of the route has been greatly developed, it is more and more of industrial significance.