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采用２００ＳＷ与０．１μｇ／ｍｌ１０－羟基喜树碱单独或联合作用于人膀胱癌细胞（ＢＴ５６３７）。实验共分四组：对照组、ＨＥＳＷ组、药物组和联合组。细胞集落形成率测定结果表明：ＨＥＳＷ能增强１０－羟基喜树碱对ＢＴ５６３７癌细胞生长抑制作用。３Ｈ－ＴｄＲ掺入试验和ＦＣＭＤＮＡ含量测定结果证明ＨＥＳＷ不仅增强１０－羟基喜树碱抑制ＢＴ５６３７癌细胞ＤＮＡ合成，而且亦可增强其抑制癌细胞分裂能力。由此，初步从细胞生物学水平阐明ＨＥＳＷ增强抗癌药物抗肿瘤作用的机理
200 SW and 0.1 μg/ml 10-hydroxycamptothecin were used alone or in combination for human bladder cancer cells (BT5637). The experiment was divided into four groups: control group, HESW group, drug group and combination group. The results of colony formation assay showed that HESW could enhance the inhibitory effect of 10-hydroxycamptothecin on BT5637 cancer cells. The results of 3H-TdR incorporation assay and FCM DNA assay demonstrated that HESW not only enhanced 10-hydroxycamptothecin inhibition of DNA synthesis in BT5637 cancer cells, but also enhanced its ability to inhibit cancer cell division. Thus, the mechanism of the anti-tumor effect of HESW enhancing anticancer drugs was initially elucidated from the level of cell biology.