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通过合成的方法将亲脂性的胆固醇接枝到亲水性的羧甲基魔芋葡甘聚糖(CKGM)链上,接枝了胆固醇的CKGM具有了两亲性,可以在水溶液中自组装形成胶束.采用ZETA-电位、透射电镜(TEM)以及荧光探针技术对其自组装行为进行了研究.结果表明,其在水溶液中的ZETA-电位为-31.8mv,其临界胶束浓度(CMC)为2.59×10-3(mg/ml),自组装形成的胶束在透射电镜下形态为球形.
The lipophilic cholesterol is grafted onto the hydrophilic carboxymethyl konjac glucomannan (CKGM) chain by a synthetic method. Cholesterol-grafted CKGM has an amphiphilic property and can be self-assembled in aqueous solution to form a gel The Zeta-Potential (Zeta-Potential), Transmission Electron Microscopy (TEM) and Fluorescence Probe were used to investigate the self-assembly behavior of the nanostructures.The results showed that the ZETA-potential in aqueous solution was -31.8mv and the critical micelle concentration (CMC) Was 2.59 × 10-3 (mg / ml). The micelles formed by self-assembly were spherical under transmission electron microscope.