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目的研究抗结核药物导致肝损害与GSTM1、GSTT1基因多态性的关系。方法收集结核病患者血标本124例,其中肝损害患者99例、非肝损害者25例。从外周血的白细胞提取DNA,用聚合酶链反应分析GSTM1及GSTT1无效基因型分布频率。结果 GSTM1、GSTT1无效基因分布频率均与肝损害呈显著正相关(P<0.01)。结论 GSTM1、GSTT1基因多态性与抗结核药导致肝损害呈正相关。
Objective To study the relationship between anti-TB drug-induced liver damage and GSTM1 and GSTT1 gene polymorphisms. Methods Totally 124 blood samples were collected from patients with tuberculosis, of which 99 were liver damage and 25 were non-liver damage. DNA was extracted from peripheral blood leukocytes and analyzed for the distribution frequency of GSTM1 and GSTT1 null genotypes by polymerase chain reaction. Results The frequency of invalid genes in GSTM1 and GSTT1 was positively correlated with liver damage (P <0.01). Conclusion The genetic polymorphisms of GSTM1 and GSTT1 are positively correlated with the liver damage induced by antituberculosis drugs.