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目的:观察鼠神经生长因子治疗带状疱疹后遗神经痛(PHN)的临床疗效。方法:选择2011年2月~2014年4月80例患者,随机分治疗组与对照组各40例,治疗组采用灭菌注射用水溶解鼠神经生长因子并加2%盐酸利多卡因1∶2给予患处注射,对照组采用醋酸曲安奈德注射液与2%盐酸利多卡因1∶4给予患处注射,2组均1次/5日,4次一疗程。观察2组患者疼痛减轻及消退时间、临床疗效及不良反应。结果:治疗组疼痛减轻时间平均为(2.87±1.0)h显著小于对照组(5.06±1.1)h,治疗组疼痛消失时间平均为(9±1.8)h明显少于对照组(12.5±2.3)h,差异有显著性(P<0.05);治疗组总有效率90%明显优于对照组62.5%,差异有显著性(P<0.05)。结论:采用鼠神经生长因子治疗带状疱疹后遗神经痛明显优于醋酸曲安奈德注射液,值得推广。
Objective: To observe the clinical efficacy of rat nerve growth factor in the treatment of postherpetic neuralgia (PHN). Methods: From February 2011 to April 2014, 80 patients were randomly divided into treatment group (40 cases) and control group (40 cases). The rats in treatment group were treated with sterile injection of water-soluble nerve growth factor and 2% lidocaine hydrochloride The patients were injected with triamcinolone acetonide acetate and 1% lidocaine hydrochloride 1: 4 in the control group. Each group was given once / 5 days and 4 times for one course of treatment. Two groups of patients were observed pain relief and regression time, clinical efficacy and adverse reactions. Results: The average pain relief time in the treatment group was (2.87 ± 1.0) h, significantly lower than that in the control group (5.06 ± 1.1) h, and the average duration of pain disappearance was (9 ± 1.8) h in the treatment group was significantly less than that in the control group (12.5 ± 2.3) h (P <0.05). The total effective rate in the treatment group was significantly higher than that in the control group (90%) (62.5%, P <0.05). Conclusion: The use of rat nerve growth factor in the treatment of postherpetic neuralgia is significantly better than triamcinolone acetonide injection, worth promoting.