目的 :了解幽门螺杆菌 (HP)相关性胃溃疡 (GU)与胃泌素 (GAS)的关系以及根除HP治疗对GAS的影响。方法 :对4 2例GU(其中HP阳性 31例 ,HP阴性 11例 )患者进行空腹胃泌素测定、胃粘膜组织活检及快速尿素酶试验测定。用洛赛克、丽珠得乐、阿莫西林及灭滴灵进行治疗。疗程 2个月 ,停药 1个月后重复上述检查。结果 :(1)HP阳性GU患者的GAS显著高于HP阴性者。 (2 )HP根除后GAS较治疗前显著降低。结论 :GAS在HP相关性胃溃疡中有重要意义 Objective: To understand the relationship between Helicobacter pylori (HP) -related gastric ulcer (GU) and gastrin (GAS) and the effect of eradication therapy on GAS. Methods: Fasting gastrin, gastric mucosal biopsy and rapid urease test were performed in 42 GU patients (including 31 HP positive and 11 HP negative). Treatment with Losec, Livzonde, amoxicillin and metronidazole. Course of 2 months, stop the drug after 1 month repeat the above examination. Results: (1) GAS in HP-positive GU patients was significantly higher than that in HP-negative patients. (2) After eradication of HP, GAS was significantly lower than before treatment. Conclusion: GAS plays an important role in HP-related gastric ulcer