论文部分内容阅读
肾功能不良时应从三方面注意合理用药: 注意对肾脏的毒性作用在肾功能不良的病人,因药物排泄延缓,使药物作用的浓度x时间增高,损肾药物对肾的毒性尤甚,可致肾功能衰竭。1.抗生素类:①氨基糖苷类:对肾近曲小管影响较大,大量长时用药及老年人、肾功不良者尤著。较轻症者先见多尿,可见蛋白尿、氨基酸尿、糖尿,血尿素氮及血浆肌酐升高;严重者致少尿性肾衰。新霉素肾毒性最大,卡那霉素次之,庆大霉素及链霉素
Renal dysfunction should pay attention to the rational use of drugs from three aspects: pay attention to the toxic effects on the kidneys in patients with renal dysfunction due to delayed drug excretion, so that the concentration of drug action x time increased, especially for renal toxicity of kidney damage drugs can be caused Renal Failure. 1. Antibiotics: ① Aminoglycosides: a greater impact on the proximal tubule of the kidney, a large number of long-term medication and the elderly, especially those with poor renal function. Slight more prevalent polyuria, visible proteinuria, amino aciduria, diabetes, blood urea nitrogen and plasma creatinine increased; severe oliguric renal failure. Neomycin nephrotoxicity, followed by kanamycin, gentamicin and streptomycin