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非小细胞肺癌(NSCLC)通常伴有p53基因的功能失活,若恢复该基因功能可抑制肿瘤生长。作者就经支气管瘤体注射腺病毒介导p53基因(Adp53)转移治疗伴有气道阻塞的NSCLC的毒性和抗肿瘤疗效进行了研究。
Non-small cell lung cancer (NSCLC) is usually associated with the functional inactivation of the p53 gene, and restoring the function of the gene inhibits tumor growth. The authors investigated the toxicity and antitumor efficacy of adenovirus-mediated p53 gene transfer (Adp53) in bronchial tumors for the treatment of airway obstruction-associated NSCLC.