纵隔的恶性纤维组织细胞瘤是一种极少见的恶性肿瘤，本文所报道的纵隔内巨大恶性纤维组织细胞瘤，笔者未见文献报道，实属罕见，现报告如下：患者男，63岁。病案号278141。无明显诱因发热2周，时有咳嗽，咯少许白色粘痰，无咯血。既往无遗传病及传染病史。体检：两肺叩诊呈清音 Mediastinal malignant fibrous histiocytoma is a rare malignant tumor. The giant malignant fibrous histiocytoma in mediastinum reported in this article has not been reported in the literature. It is rare. The report is as follows: The patient is male, 63 years old. Case number 278141. No obvious cause of fever for 2 weeks, when there is cough, slightly white sticky sputum, no hemoptysis. No previous history of genetic diseases and infectious diseases. Physical examination: two lungs percussion was clear voice