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目的探讨和评价母亲血糖异常对所生子女的影响。方法选择母亲糖尿病合并妊娠的儿童286例,母亲怀孕期间患有妊娠期糖尿病的儿童278例,与母亲无血糖异常的儿童310例,分别空腹静脉采血进行胰岛自身抗体[胰岛细胞抗体(ICA)、胰岛素抗体(IAA)、谷氨酸脱羧酶抗体(GAD)等]测定,进行比较。结果母亲有妊娠期糖尿病或妊娠合并糖尿病的儿童组中,胰岛自身抗体阳性检出率明显高于对照组(P<0.01),差异有统计学意义。结论母亲有妊娠期糖尿病或糖尿病合并妊娠的儿童今后患糖尿病的几率高于母亲怀孕期间无血糖异常的儿童。
Objective To investigate and evaluate the impact of maternal glucose abnormalities on children born. Methods 286 cases of mothers with diabetes mellitus complicated by pregnancy, 278 cases of gestational diabetes during pregnancy and 310 cases of mothers without blood glucose abnormalities were selected. Blood samples were collected from fasting venous blood for islet autoantibodies (ICA, Insulin antibody (IAA), glutamic acid decarboxylase antibody (GAD), etc.] were measured and compared. Results In the children with gestational diabetes mellitus or gestational diabetes mellitus, the positive rate of islet autoantibodies was significantly higher than that of the control group (P <0.01). The difference was statistically significant. CONCLUSIONS: Children with mothers with gestational diabetes or diabetes complicated with pregnancy have a higher risk of developing diabetes in the future than mothers with non-glycemic abnormalities during pregnancy.