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Objective:To explore the clinical therapeutic effects and the mechanism on rheumatic arthritis (RA) treated with the combination of the instruments and techniques of acupuncture and moxibusiton.Methods:A total of 60 RA patients were randomized into an observation group and a control group,30 cases in each one.In the control group,diclofenac sodium sustained release tablets were prescribed for oral administration,0.3 g each time,twice a day,methotrexate tablets (MTX) for oral administration,10 mg each time,once a week and folic acid tablets for oral administration,5 mg each time,once a week.In the observation group,besides the treatment with western medicines,simultaneously,the specific acupoints were selected and stimulated with the triple strong-stimulation therapy,in which,the strong bloodletting technique,the strong cupping technique and the strong moxibustion technique were combined together,with different instruments of acupuncture and moxibustion adopted.The treatment was given once every 3 days,consecutively for 10 times.In 30 days of treatment,the therapeutic effects were observed in the two groups.Separately,before and after treatment,the rheumatoid factors (RF),hypersensitive-C reactive protein (hs-CRP) and erythrocyte sedimentation rate (ESR),the scores of joint symptoms and physical signs as well as the disease activity score (DAS-28) were observed in the two groups.Results:Regarding RF,there were statistical significant differences before and after treatment in the observation group and the control group (the observation group 248.01 ± 79.81 vs 31.17 ± 29.01,the control group 254.11 ± 72.16 vs 66.42 ± 37.07,both P ＜ 0.05).The result in the observation group was lower significantly than the control group after treatment (P ＜ 0.05).Regarding hs-CRP,there were statistical significant differences before and after treatment in the observation group and the control group (the observation group 26.12 ± 9.22 vs 8.98 ± 7.66,the control group 23.18 ± 7.18 vs 16.01 ± 5.02,both P ＜ 0.05).The result in the observation group was lower significantly than the control group after treatment (P ＜ 0.05).Regarding ESR,there were statistical significant differences before and after treatment in the observation group and the control group (the observation group 30.56 ± 11.38 vs 12.58 ± 5.91,the control group 35.52 ± 9.67 vs 21.47 ± 6.91,both P ＜ 0.05).The result in the observation group was lower significantly than the control group after treatment (P ＜ 0.05).Regarding DAS-28,there were statistical significant differences before and after treatment in the observation group and the control group (the observation group 8.89 ± 2.01 vs 3.01 ± 0.74,the control group 8.14 ± 1.38 vs 4.12 ± 0.96,both P ＜ 0.05).The result in the observation group was lower significantly than the control group after treatment (P ＜ 0.05).Regarding the quantitative grading score of symptom,there were statistical significant differences before and after treatment in the observation group and the control group (the observation group 7.87 ± 1.69 vs 3.82 ± 1.96,the control group 7.77 ±1.68 vs 5.01 ± 11.23,both P ＜ 0.05).The result in the observation group was lower significantly than the control group after treatment (P ＜ 0.05).The total effective rate was 96.67％ (29/30) in the observation group and was 80.0％ (24/30) in the control group,indicating the statistical significant difference between the two groups (P ＜ 0.01).Conclusion:Based on western medications,the triple strong-stimulation therapy of acupuncture and moxibustion at specific acupoints significantly relieves the joint symptoms,reduces the inflammatory reaction indicators and improves the clinical therapeutic effects on RA in the patients.