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肾结石是当今一顽疾。手术除石为重要对策,然而未能阻止其复发,复发率甚至可高达80%。近年来,随着对结石形成机制的深入研究,采用口服药物防治肾结石,尤其是特发性肾结石,取得较多进展。肾结石的晶体成份,约3/4以上含钙盐,其中以草酸钙为最多。结石之所以形成,主要取决于尿液所含晶体饱和度与尿液抑制活力之比。因此,药物治疗旨在减少尿钙等晶体成分和/或增加尿液抑制活力。正磷酸盐(Orthophosphate) 目前用于防治肾结石的各种‘磷’制剂中,应用最广,疗效较好而副作用较少的是正磷酸盐。临床上约有2/3肾结石无明确病因可查,此种所谓特发性肾结石的治疗最棘手。其
Kidney stones are a stingy illness today. In addition to stone surgery as an important countermeasure, however, failed to prevent its recurrence rate can be as high as 80%. In recent years, with the in-depth study on the mechanism of stone formation, the use of oral drugs to prevent kidney stones, especially idiopathic kidney stones, made more progress. Crystal of kidney stones, about 3/4 or more calcium salts, of which calcium oxalate is the most. The reason for the formation of stones depends mainly on the ratio of the crystal’s saturation of urine to the inhibitory activity of urine. Therefore, medical treatment aims to reduce the urinary calcium and other crystal components and / or increase urine inhibitory activity. Orthophosphate Orthophosphate is the most widely used, effective and less harmful side-effect of various phosphorus preparations currently used in the prevention and treatment of kidney stones. Clinically, about 2/3 of kidney stones without a clear cause can be investigated, the so-called treatment of idiopathic kidney stones the most intractable. its