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磺胺药是比较常用的抗菌药,抗菌谱较广,而且具有性质稳定、价格比较便宜、使用方便,既有口服易吸收又有口服不易吸收之制剂等优点。临床应用广泛。在使用磺胺类药物时应注意以下几点。 1.严格掌握适应证。磺胺药主要适应证为:①流行性脑脊髓膜炎:磺胺嘧啶为首选药。因该药与血浆蛋白结合率低,脑脊液中分布浓度高,疗效好。多主张与青霉素联合使用。②泌尿道感染:泌尿道感染主要致病菌为大肠杆菌,其次为变形杆菌、葡萄球菌、
Sulfa drugs are more commonly used antibacterial drugs, antimicrobial spectrum broader, and has the properties of stable, cheaper, easy to use, both oral absorption and oral absorption of the preparation is not easy and so on. Wide range of clinical applications. The use of sulfonamides should pay attention to the following points. 1. Strict control of indications. Sulfa drug main indications: ① epidemic cerebrospinal meningitis: sulfadiazine is the drug of choice. Due to the drug and plasma protein binding rate is low, high concentration of cerebrospinal fluid distribution, good effect. More advocates and penicillin joint use. ② urinary tract infection: urinary tract infection is the main pathogen Escherichia coli, followed by Proteus, Staphylococcus aureus,