患者,男,60岁,干部,蒙族。于2年前无明显诱因,发现面部,双手,双脚趾及下腹部皮肤逐渐变黑,后扩至全身皮肤,伴有小棘洋突起。头颈部最多,偶发痒。近半年来双手指、掌,双足趾蹠出现角化。于85年未经X线胃肠透视及胃镜检查诊为“贲门癌”。在探查术中广泛粘连未能切除,近于86年3月经北京中日友谊 Patient, male, 60 years old, cadre, Mongolian. No obvious cause was found 2 years ago. It was found that the skin on the face, hands, both toes and lower abdomen gradually darkened, and then spread to the whole body’s skin with small spinous processes. Most head and neck, itching. In the past six months, keratinization has occurred in fingers, palms, and toes. In the 85 years without X-ray gastrointestinal perspective and gastroscopy diagnosed as “cardia cancer.” Extensive adhesions failed to be removed during exploratory surgery. The friendship between Beijing and China in March of the year ended March 86