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本实验以昆明种小白鼠为模型，采用氯化锂经口饮水喂饲染毒，观察了锂对仔鼠神经行为发育的影响。结果表明：染毒组仔鼠体格发育、早期生理发育均显著滞后于对照组（Ｐ＜０．０５，Ｐ＜０．０１），神经行为发育迟缓，学习能力和记忆能力均明显减退。由此提示：锂染毒后不仅可损伤母鼠，而且可通过胎盘屏障作用于子代，影响其中枢神经系统的生长发育，导致神经行为发育异常。
In this study, Kunming mice as a model, the use of lithium chloride oral water feeding poisoning observed the effects of lithium on neurobehavioral development of pups. The results showed that the physical development and early physiological development of the offspring rats were significantly delayed than the control group (P <0.05, P <0.01), neurobehavioral development retardation, learning ability and memory ability were significantly decreased. Thus, it is suggested that not only the mother rats can be injured after exposure to lithium, but also the progeny can be affected by the placental barrier, affecting the growth and development of the central nervous system and leading to abnormal neurobehavioral development.