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甲氟喹是一种新喹啉甲醇衍生物,它对动物和人的各种疟疾均有较高疗效,并能控制对氯喹耐药的恶性疟原虫,故已被WHO确认为一种有希望的新抗疟药。本文报道19例男性志愿者口服甲氟喹一次给药的药代动力学。6例白人中有3例一次口服250mg,另3例一次口服1,000mg;8例非洲人一次口服1,000mg;另有5例非洲人总药量1,000mg,分三天口服(500、250和250mg)。吸收:滞留时间不到30分钟,接着血浆
Mefloquine, a new quinolinemethanol derivative, has been recognized by WHO as a promising alternative to chloroquine-resistant Plasmodium falciparum due to its high efficacy against various malaria in animals and humans New antimalarial drug. This article reports the pharmacokinetics of a single oral administration of mefloquine to 19 male volunteers. Three of the six white men received 250 mg orally at one time and the other three took 1,000 mg orally at one time; eight African Americans received 1,000 mg orally at one time; and five African Americans received a total dose of 1,000 mg orally in three days (500, 250 and 250 mg ). Absorption: retention time less than 30 minutes, followed by plasma