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头孢哌酮具有抗菌谱广、抗菌作用强,血浓度高、t_(1/2)长等特点。本文应用家兔测定本品的肝肾毒性及组织分布。头孢哌酮400mg/(kg·d)连续15d,动物的肝肾功能、血钾、血钠、凝血酶元时间,血小板计数等无明显改变,但病理检查发现头孢哌酮可引起肾近曲小管灶性坏死,集合管内有颗粒管型,肝脏灶性坏死,片状出血或坏死现象,比头孢孟多明显。静脉注射后能迅速分布至各组织,尿、胆汁和肾组织浓度超过同时期血浓度;多次连续给药后,胆汁及肝脏浓度有增加的倾向。头孢哌酮在多数组织中浓度超过头孢孟多。
Cefoperazone has broad antibacterial spectrum, strong antibacterial effect, high blood concentration, t_ (1/2) long and so on. In this paper, rabbit liver and kidney toxicity and tissue distribution determination of the goods. Cefoperazone 400mg / (kg · d) for 15 days, animal liver and kidney function, serum potassium, serum sodium, thrombin time, platelet count and other no significant change, but the pathological examination found that cefoperazone can cause renal proximal tubule Focal necrosis, the collection tube with granular tube type, focal hepatic necrosis, flaky hemorrhage or necrosis, more obvious than the cephalosporins Meng. After intravenous injection can be quickly distributed to all tissues, urine, bile and kidney tissue concentration over the same period of blood concentration; after repeated administration, the bile and liver concentrations tend to increase. Cefoperazone concentration in most tissues more than cephalosporin.