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1例61岁男性患者因腰椎间盘突出症口服美索巴莫0.5 g，1次/d。6 d后，腰痛缓解，自行停药。6d后，因腰痛加重再次服用相同剂量美索巴莫。再次用药后第7天，患者出现皮肤黄染、尿色加深，伴有食欲减退。6 d后，因厌食而自行停药。实验室检查：丙氨酸转氨酶（ ALT）1369 U/L，天冬氨酸转氨酶（ AST）1198 U/L，直接胆红素（ DBil）87.1μmol/L，间接胆红素（ IBil）75.4μmol/L。诊断为药物性肝损伤。给予谷胱甘肽（1.8 g，1次/d）和异甘草酸镁（0.1 g，1次/d）静脉滴注。1 d后复查：ALT 1331 U/L，AST 503 U/L，DBil 73.9μmol/L，IBil 68.9μmol/L。13 d后肝功能复查：ALT 131 U/L，AST 71 U/L，DBil 34.5μmol/L，IBil 45.0μmol/L。改为口服谷胱甘肽（0.4 g，3次/d）和甘草酸二铵（0.15 g，3次/d）。1个月后随访，患者黄染消退，ALT 19 U/L，AST 11 U/L，DBil 1.3μmol/L，IBil 11.4μmol/L。“,”A 61-year-old male patient with lumbar disc herniation received oral methocarbamol 0. 5 g twice daily. On day 6 of treatment,the lumbago was alleviated and the patient stopped the drug without permissions. Six days later,he took the same dose of methocarbamol for worsened lumbago. On day 7 of treatment with methocarbamol again,the patient developed icteric skin,dark urine and anorexia. Six days later,the patient stopped the drug again due to apocleisis. Laboratory tests showed the following results:alanine aminotransferase( ALT)1 369 U/L,aspartate aminotransferase( AST)1 198 U/L,direct bilirubin( DBil)87. 1 μmol/L,indirect bilirubin( IBil)75. 4 μmol/L. Drug-induced liver injury was diagnosed. He received IV infusions of glutathione 1. 8 g once daily and magnesium isoglycyrrhizinate 0. 1 g once daily. Two days later,laboratory tests showed the following results:ALT 1 331 U/L,AST 503 U/L, DBil 73. 9 μmol/L,IBil 68. 9 μmol/L. Thirteen days later,repeat liver function tests showed the following levels:ALT 131 U/L,AST 71 U/L,DBil 34. 5 μmol/L,IBil 45. 0 μmol/L. His therapy was changed to oral glutathione 0. 4 g thrice daily and diammonium glycyrrhizinate 0. 15 g thrice daily. His jaundice subsided at follow up after one month,and liver function tests showed the following levels:ALT 19 U/L, AST 11 U/L,DBil 1. 3 μmol/L,IBil 11. 4 μmol/L.