CHOP/GADD153是内质网应激反应特异的转录因子,参与各种细胞活动特别是能量代谢、增殖、分化、凋亡的调节。CHOP在正常情况下表达很低,在内质网应激反应时表达显著升高。CHOP介导的凋亡通路是内质网应激相关凋亡通路中的重要途径。本文综述了CHOP/GADD153介导的细胞凋亡与肿瘤研究的新进展,对于肿瘤的生物治疗具有一定的参考价值。 CHOP / GADD153 is an endoplasmic reticulum stress response-specific transcription factor involved in various cell activities, especially energy metabolism, proliferation, differentiation, apoptosis regulation. CHOP expression is very low in normal circumstances, endoplasmic reticulum stress response was significantly increased. CHOP-mediated apoptosis pathway is an important pathway in ER stress-related apoptosis pathway. This review summarizes the new progress of CHOP / GADD153-mediated apoptosis and tumor research, which is of certain reference value for the biological treatment of tumors.