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目的观察米非司酮配伍依沙吖啶羊膜腔内注射用于中期妊娠引产的临床效果。方法将200例中期妊娠要求引产孕妇随机分为观察组及对照组各100例,观察组给予米非司酮配伍依沙吖啶羊膜腔内注射引产,对照组行依沙吖啶羊膜腔内注射引产。观察2组依沙吖啶羊膜腔注射至宫缩发动时间,宫缩发动时至胎儿排出时间,引产成功例数,产后2h出血量,胎盘、胎膜残留情况,宫颈裂伤例数,难忍性疼痛例数情况。结果观察组依沙吖啶羊膜腔注射至宫缩发动时间、宫缩发动时至胎儿排出时间及总产程均短于对照组,差异均有统计学意义(P<0.05)。2组引产成功率比较差异无统计学意义(P>0.05)。观察组宫缩时宫颈Bishop评分高于对照组,产后2h出血量少于对照组,胎盘、胎膜残留、宫颈裂伤、宫缩引起难忍性疼痛的发生率均低于对照组,差异均有统计学意义(P<0.05)。结论米非司酮联合依沙吖啶引产可有效地软化宫颈,避免宫颈裂伤,加快胎儿胎盘排除时间,减少产后出血量,减轻患者因引产带来的难忍性疼痛,有助于产后恢复。
Objective To observe the clinical effect of mifepristone combined with amniotic fluid injection of amniotic fluid for induction of labor in mid-term pregnancy. Methods Two hundred pregnant women were randomly divided into observation group and control group. The observation group was treated with mifepristone combined with ethacridine, Induction. The incidence of uterine contractions, the number of cases of cervical laceration, the number of cases of cervical laceration, the number of cases of cervical laceration, The number of cases of sexual pain. Results In the observation group, the intracameral injection of amniotic acridine was shorter than that of the control group (P <0.05). There was no significant difference in success rate of induction of labor between the two groups (P> 0.05). The Bishop score of the observation group was higher than that of the control group, and the amount of bleeding 2 hours after delivery was less than that of the control group. The incidence of placenta, residual fetal membranes, cervical laceration and uterine contractions caused by unilateral pain were lower than those of the control group There was statistical significance (P <0.05). Conclusion Mifepristone combined with ethacridine induction can effectively soften the cervix to avoid cervical laceration, accelerate fetal placenta exclusion time, reduce postpartum hemorrhage, reduce the unpleasant pain caused by induction of labor, contribute to postpartum recovery .