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目的 研究渗透促进剂对大黄流浸膏透皮释放的影响。方法 采用分光光度法，以大黄素为指标进行大黄流浸膏的体外透皮释放测定。结果 以累积渗透药量对时间作线性回归，得回归方程，并对各项下所得Ｋ 值作方差分析，不同促进剂对大黄流浸膏的透过率影响极显著。结论：２０ ｇ／Ｌ 月桂醇硫酸钠透皮促进作用最强，而２０ ｇ／Ｌ的吐温８０ 和２０ ｇ／Ｌ氮酮几乎无促进作用。
Objective To study the effect of penetration enhancers on the transdermal delivery of Rhubarb. Methods Spectrophotometry was used to determine the transdermal delivery of rhubarb extract in vitro with emodin as an index. The results of cumulative dose of permeation on the time for linear regression, the regression equation, and under the K value for each analysis of variance, the different accelerator on the permeability of rhubarb extract significantly affected. CONCLUSION: The transdermal promoting effect of 20 g / L sodium lauryl sulfate was the strongest, while 20 g / L of Tween 80 and 20 g / L azone had almost no promotion effect.