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为了解淋球菌对氟喹诺酮类药物的耐药性 ,用琼脂稀释法和纸片扩散法分别对 1998～ 1999年间广东省湛江地区分离出的 98株淋球菌流行株进行了药物敏感性测定。测定了流行株对诺氟沙星、依诺沙星、环丙沙星、氧氟沙星和洛美沙星 5种氟喹诺酮类药物的最小抑菌浓度 (MIC)和抑菌圈直径 (mm) ,根据NCCL S标准判定敏感与耐药。结果表明 ,纸片扩散法测定淋球菌对这 5种抗生素的耐药百分率分别为91.84%、97.96 %、84.70 %、75 .71%和 87.76 %,而琼脂稀释法相应的耐药百分率为 83.5 0 %、91.2 0 %、5 9.30 %、5 3.80 %和 75 .80 %。结果提示 ,湛江地区淋球菌流行株对氟喹诺酮类药物耐药现象十分普遍 ,临床医生进行淋病治疗时要引起高度重视。
To understand the drug resistance of gonococci to fluoroquinolones, 98 strains of Neisseria gonorrhoeae isolated from Zhanjiang, Guangdong Province from 1998 to 1999 were tested for their drug sensitivity by agar dilution method and disk diffusion method. The minimum inhibitory concentration (MIC) and bacteriostatic circle diameter (mm) of five fluoroquinolones, including norfloxacin, enoxacin, ciprofloxacin, ofloxacin and lomefloxacin, , According to the NCCL S standard to determine sensitive and resistant. The results showed that the percentage of drug resistance of Neisseria gonorrhoeae to these 5 antibiotics was 91.84%, 97.96%, 84.70%, 75.71% and 87.76%, respectively, while the corresponding drug resistance rate of Agar dilution method was 83.5 0 %, 91.2 0%, 5 9.30%, 5 3.80% and 75 .80%. The results suggest that endemic strains of Neisseria gonorrhoeae in Zhanjiang fluoroquinolones resistance is very common, clinicians should pay attention to gonorrhea treatment.