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以质量分数为98%的甲酸为溶剂,将再生丝素与明胶以质量比70∶30进行共混静电纺丝。研究纺丝液质量分数及乙醇处理对纤维膜的结构及力学、溶解性能等的影响;测定不同纺丝液质量分数及不同厚度下纤维膜的孔隙率及孔径;在纤维膜上进行小鼠成纤维细胞(L929)和人脐静脉内皮细胞(HUVECs)培养实验。结果表明:随着纺丝液质量分数的提高或经乙醇处理后,丝素β化程度提高,纤维结晶度增大,溶失率减小,拉伸强度增大;随着纺丝液质量分数的提高,纤维膜的孔隙率减小,孔径增大,厚度增加时,纤维膜的孔隙率及孔径均减小;L929及HUVECs均能够在纳米纤维膜上黏附、生长和增殖。
The mass fraction of 98% formic acid as a solvent, the regenerated silk fibroin and gelatin mass ratio of 70:30 were blended electrospinning. The effects of spinning solution mass fraction and ethanol treatment on the structure, mechanical properties and dissolution properties of the fiber membrane were investigated. The porosity and pore size of the fiber membrane were measured at different spinning solution mass fractions and thicknesses. Fibroblast (L929) and human umbilical vein endothelial cells (HUVECs) culture experiments. The results showed that with the increase of the mass fraction of spinning solution or ethanol treatment, the degree of fibroin β increased, the fiber crystallinity increased, the dissolution rate decreased and the tensile strength increased. With the mass fraction of spinning solution , The porosity of fiber membrane decreased and the pore diameter increased. When the thickness increased, the porosity and pore size of fiber membrane decreased. Both L929 and HUVECs could adhere, grow and proliferate on the nanofiber membrane.