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目的通过了解核潜艇长航前后艇员白细胞和淋巴细胞数量及T淋巴细胞集落形成率的变化,探讨长航应激因素对艇员机体免疫的影响。方法分别采集核潜艇艇员出航前后外周血标本,经血液分析仪检测,比较长航前后艇员外周血白细胞总数和淋巴细胞数;培养出航前后外周血淋巴细胞,检测长航前后T淋巴细胞集落数。结果①长航前核潜艇艇员外周血白细胞总数为(6 625.71±948.39)个/ml。长航后下降至(6 114.29±929.94)个/ml(P<0.05),外周血淋巴细胞数则由长航前(2 340.00±325.58)个/ml升高到长航后的(2 577.14±343.07)个/ml(P<0.05);②长航前核潜艇艇员外周血T淋巴细胞集落形成率为(39.99±14.30)个/2×104MNC,长航后增高至(65.85±16.80)个/2×104MNC(P<0.01)。结论核潜艇长航应激因素对艇员外周血白细胞计数及T淋巴细胞集落形成率产生影响。
Objective To understand the changes of white blood cells and lymphocytes and the rate of T lymphocyte colony formation before and after the nuclear submarine long flights and to explore the impact of long-term stress factors on the immunity of the crew. Methods Peripheral blood samples of nuclear submarine sailors before and after departure were collected and detected by hematology analyzer. The total number of leukocytes and lymphocytes in peripheral blood before and after long voyage were compared. Peripheral blood lymphocytes were cultured before and after flight, and the number of T lymphocytes . Results ① The total number of leukocytes in the long submarine crew was (6 625.71 ± 948.39) / ml. After long voyage, the number of peripheral blood lymphocytes decreased to (6 114.29 ± 929.94) / ml (P <0.05), and the number of peripheral blood lymphocytes increased from 2 340.00 ± 325.58 / ml before long voyage to 2 577.14 ± 343.07) cells / ml (P <0.05) .②The peripheral blood T lymphocyte colony formation rate of long sail pre-nuclear submariners was (39.99 ± 14.30) / 2 × 104MNC and increased to (65.85 ± 16.80) / 2 × 104MNC (P <0.01). Conclusion The stress factors of nuclear submarines affect the white blood cell count of peripheral blood and the rate of T lymphocyte colony formation.