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目的探讨P53在乳腺癌中的表达及其与预后的关系。方法收集2007～2010年乳腺癌仿根治术标本81例,采用免疫组化法检测乳腺癌中P53、ER、PR和C-erbB-2的表达,并分析P53与预后因子ER、PR和C-erbB-2及淋巴结转移的关系。结果 P53阳性率为84.0%,其表达与预后正性因子ER、PR呈负相关,而与预后负性因子C-erbB-2、腋窝淋巴结转移呈正相关,其差异有统计学意义(P<0.05)。结论 P53高表达是乳腺癌预后的负性相关因子之一。
Objective To investigate the expression of P53 in breast cancer and its relationship with prognosis. Methods Totally 81 cases of mimicking radical mastectomy were collected from 2007 to 2010. The expressions of P53, ER, PR and C-erbB-2 in breast cancer were detected by immunohistochemistry. The expressions of P53 and prognostic factors ER, PR and C- erbB-2 and lymph node metastasis. Results The positive rate of P53 was 84.0%. The expression of P53 was negatively correlated with the prognosis positive factor ER and PR, but positively correlated with the negative prognostic factor C-erbB-2 and axillary lymph node metastasis (P <0.05 ). Conclusion The high expression of P53 is one of the negative correlates of breast cancer prognosis.