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用I~(131)标記血清蛋白及P~(32)标記紅血球研究海南島蘿芙木根硷对循环及器官血浆及血球容量的影响,发見: (一)正常或腎型高血压大白鼠靜脉注射此硷5毫克/公斤,5分鉀后,循环血浆及血球量均无明显影响。 (二)此硷能使正常大白鼠肺血管扩张,使腎型高血压大白鼠心肌、腎、肝等器官的缺血状态得到改善。 (三)小白鼠灌胃此硷100毫克/公斤,30分鉀后肝、脾及腎的比放射性减低,90分钟后肺的計数率則增高,提示此硷可能扩张肺血管。 (四)大白鼠腹腔注射此硷180分鉀內血管通透性无改变,因此訊为此时器官比放射性的变化应該主要用血管本身的舒縮和充盈的改变来解释。
I ~ (131) labeled serum protein and P ~ (32) labeled erythrocyte Hainan Island Rauwolfin alkali on the circulation and organ blood plasma and blood volume, see: (A) of the normal or renal hypertensive large Rats intravenous injection of this base 5 mg / kg, 5 potassium, no significant effect on circulating plasma and blood volume. (B) The alkaline can make the normal rat pulmonary vascular dilatation, renal hypertensive rats myocardial, kidney, liver and other organs of the ischemic status is improved. (C) mice fed the alkaline 100 mg / kg, 30 minutes after the liver, spleen and kidney radioactivity decreased, 90 minutes after the count rate of the lung is increased, suggesting that the alkaline may expand the pulmonary vessels. (D) intraperitoneal injection of this alkaline 180 points potassium within the vascular permeability was unchanged, so the news for the organ at this time than the radioactive changes should be mainly used to explain the vascular contraction and filling their own changes.