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目的:观察血必净注射液辅助治疗老年脓毒性休克的疗效。方法:选择老年脓毒性休克63例,随机分为对照组31例和观察组32例。对照组按照脓毒性休克国际治疗指南进行常规综合治疗,观察组在对照组治疗的基础上加用血必净注射液。分别在治疗前及治疗后第1、3、7天检测两组血小板计数(PLT)、凝血酶原时间(PT)、活化部分凝血酶时间(APTT)、D-二聚体(D-D)、纤维蛋白原(FIB),并比较两组多器官功能障碍(MODS)发病率与病死率。结果:与对照组同一时段比较,治疗后第3天及第7天,观察组PLT显著增高,PT、APTT、D-D、FIB显著或非常显著降低(P<0.05,P<0.01);观察组MODS发生率15.6%,病死率6.25%,均显著或非常显著低于对照组(P<0.05,P<0.01)。结论:血必净注射液对老年脓毒性休克的凝血功能有保护作用,可降低老年脓毒性休克MODS的发生率和病死率。
Objective: To observe the effect of Xuebijing Injection in the treatment of senile septic shock. Methods: Seventy-three elderly patients with septic shock were randomly divided into control group (n = 31) and observation group (n = 32). The control group according to the international guidelines for the treatment of septic shock for conventional comprehensive treatment, the observation group in the control group based on the treatment with Xuebijing injection. The platelet counts (PLT), prothrombin time (PT), activated partial thromboplastin time (APTT), D-dimer (DD), fiber (FIB), and compared morbidity and mortality of multiple organ dysfunction (MODS) in two groups. Results: Compared with the control group at the same time point, the PLT in the observation group was significantly increased, the PT, APTT, DD, FIB were significantly or very significantly decreased on the 3rd and 7th day after treatment (P <0.05, P <0.01) The incidence rate was 15.6% and the case fatality rate was 6.25%, both significantly and significantly lower than those in the control group (P <0.05, P <0.01). Conclusion: Xuebijing Injection has the protective effect on the coagulation function of senile septic shock, and can reduce the morbidity and mortality of MODS in senile septic shock.