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通过近年来大骨节病生物化学的研究,可将其生物化学代谢特点归纳为以下四个方面: 一、以低硒为中心的代谢紊乱大骨节病区的外环境是低硒地区,生物化学检查表明,大骨节病人不仅血硒,发硒和尿硒含量低,红细胞膜硒低,而且患者血液中谷胱甘肽过氧化物酶的活性也低于健康者。病人血中脂质过氧化物和血浆游离脂肪酸的含量,都明显高于非病区对照人群。谷胱甘
In recent years, Kashin-Beck disease biochemistry research, its biochemical metabolic characteristics can be summarized as the following four aspects: First, the low selenium as the center of the metabolic disorder Kashin-Beck area of the external environment is low selenium areas, biochemical tests The results showed that not only blood selenium, selenium and urinary selenium, but selenium of erythrocyte membrane were low, and the activity of glutathione peroxidase in blood was also lower than that of healthy patients. Patient blood lipid peroxide and plasma free fatty acid content, were significantly higher than non-ward control population. Glutathione