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应用CD系统单克隆抗体(McAb)对364例异体肾移植受者进行814次外周血T淋巴细胞亚群检测,观察到应用免疫抑制剂环孢素A(CsA)治疗后CD4+/CD8+较用CsA前明显降低(P<0.01)。动态观察发现,急性排斥反应发生时CD4+/CD8+回升,当比值>1.2时,提示有排斥危险,与未排斥组相比,该值明显升高(P<0.01)。对14例感染患者的监测结果显示,感染时CD4+/CD8+下降。对34例应用CD3、CD4McAb治疗者的监测结果显示,用McAb治疗后,CD3+、CD4+及CD4+/CD8+均明显下降。
814 peripheral blood T lymphocyte subsets were detected in 364 allogeneic kidney transplant recipients by using CD system monoclonal antibody (McAb). The results showed that CD4 + / CD8 + Before significantly lower (P <0.01). Dynamic observation showed that CD4 + / CD8 + was up when acute rejection occurred. When the ratio was> 1.2, there was a risk of rejection, which was significantly higher than that in non-rejection group (P <0.01). Monitoring of 14 infected patients showed that CD4 + / CD8 + decreased during infection. The monitoring results of 34 patients treated with CD3 and CD4McAb showed that the levels of CD3 +, CD4 + and CD4 + / CD8 + were significantly decreased after treatment with McAb.