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目的探索流感流行规律 ,制定防制方案 ,有效预防流感。方法对门诊就诊的上感病例进行流行病学观察 ;采用常规鸡胚双腔法分离流感病原 ;并用微量血凝抑制试验 (HI)法测定人群免疫水平。结果 1999年及2 0 0 0年未检出流感病原 ,2 0 0 1年分离到A1(H1N1)亚型流感病原 12株。正常人群免疫水平 ,1999年以A3 (H3N2 )亚型阳性率最高 ,占 79 2 5 % (GMT62 78) ;2 0 0 0年以A1(H1N1)亚型阳性率最高 ,占 88 68% (GMT79 42 ) ;2 0 0 1年以A1(H1N1)亚型阳性率最高 ,占 76 40 % (GMT5 4 2 8)。两系乙型流感中本市只有一个系在人群中有抗体 ,另一系在低年龄组人群中未检出抗体。结论 2 0 0 1年本市局部发生A1(H1N1)亚型流感流行。人群中A1型流感免疫水平较高 ,如果没有发生抗原变异 ,今年A1型流感流行的可能性不大。但A3 (H3N2 )及乙型流感免疫水平较低 ,应加强防范
Objective To explore the prevalence of influenza, develop control programs and effectively prevent influenza. Methods Epidemiological observation was conducted on outpatients with upper flu symptoms. Influenza pathogens were isolated by conventional chick embryo double chamber method and the level of immunity of the population was determined by micro-hemagglutination inhibition test (HI). Results No pathogen was detected in 1999 and 2000, and 12 pathogens of A1 (H1N1) subtype were isolated in 2001. In 1999, the positive rate of A3 (H3N2) subtype was the highest, accounting for 79.25% (GMT6278). The highest prevalence of A1 (H1N1) subtype was 88% (GMT79) in 2000 42). The highest positive rate of A1 (H1N1) subtype was 76 40% (GMT5 428) in 2001. Two strains of influenza B in the city only one antibody in the population, while the other in the low-age group did not detect antibodies. Conclusion The prevalence of A1 (H1N1) subtype influenza in this city in 2001. A1 in the crowd a higher level of immunity, if no antigenic variation, the prevalence of this year’s type A1 influenza is unlikely. However, A3 (H3N2) and influenza B immunity is low, should be strengthened to prevent