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目的探讨纤维蛋白和纤维蛋白原基序拮抗剂gamma117-133肽对兔动脉粥样硬化(AS)影响。方法新西兰白兔24只均分为三组。对照组兔不行球囊导管损伤术,喂养正常饮食;模型组兔实施2F球囊导管损伤血管内膜,给予高脂饮食12周,建立颈总动脉AS兔模型;干预组兔按模型组处理,但在导管损伤血管后又经球囊导管将gamma117-133肽导入损伤血管的周围。应用共聚焦显微镜观察AS病理改变,原位杂交检测基质金属蛋白酶2(MMP-2)的表达和凋亡情况。结果干预组AS斑块内MMP-2表达和凋亡水平显著低于模型组,而与对照组相仿。结论 Gamma117-133肽对兔AS斑块有抗炎和抗凋亡作用,有利于减轻AS病变程度和稳定AS斑块。
Objective To investigate the effect of fibrin and fibrinogen motif antagonist gamma117-133 peptide on atherosclerosis (AS) in rabbits. Methods 24 New Zealand white rabbits were divided into three groups. The rabbits in the control group were given balloon catheter ablation and fed with normal diet. The model rabbits were given 2F balloon catheter to injure the intima of the vessel, and then given a high-fat diet for 12 weeks to establish the carotid artery AS rabbit model. The rabbits in the intervention group were treated by the model group, However, after the vessel was damaged, the gamma117-133 peptide was introduced into the injured vessel via the balloon catheter. The pathological changes of AS were observed by confocal microscopy. The expression of MMP-2 and apoptosis were detected by in situ hybridization. Results The expression of MMP-2 and the level of apoptosis in AS plaques in intervention group were significantly lower than those in model group, but similar to those in control group. Conclusion Gamma117-133 peptide has anti-inflammatory and anti-apoptotic effects on AS plaques in rabbits, which is beneficial to reduce the severity of AS and stabilize AS plaques.