本研究系用免疫酶标蛋白A法(HRP-SPA)检测53例胃癌手术切除标本的血型物质消减情况。血型物质总消减率为73.6%,低分化腺癌较高分化腺癌血型物质消减显著(P<0.05);有局部淋巴结转移的较无转移者消减显著(P<0.01);术后存活不足5年较超过5年者消减显著(P<0.01)。作者认为,癌细胞形态学上的去分化与免疫学上的去分化并非总是完全一致的。 In this study, immunohistochemically labeled protein A method (HRP-SPA) was used to detect blood substance depletion in 53 cases of gastric cancer. The total elimination rate of blood group substances was 73.6%, and the blood group substances of poorly differentiated adenocarcinomas were significantly lower (P<0.05); the patients with regional lymph node metastases were significantly reduced (P<0.01); the postoperative survival was less than 5%. Years more than 5 years were significantly reduced (P <0.01). The authors believe that the dedifferentiation of cancer cells in morphology is not always consistent with the dedifferentiation in immunology.