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本文探讨瘤体内注射ＤＮＣＢ溶液对小鼠移植性肿瘤的治疗效果及其作用机理。结果表明，瘤体内注射ＤＮＣＢ溶液对昆明种小鼠的艾氏实体瘤有明显疗效，可有效抑制肿瘤生长，使肿瘤体积缩小直至完全消退，小鼠寿命显著延长，同时可使小鼠获得抵抗肿瘤再次接种的全身免疫力。病理组织学研究结果表明，瘤体内注射ＣＮＣＢ溶液既可直接引起瘤体组织坏死，又能在瘤体局部产生具有细胞免疫反应特点的淋巴细胞浸润，说明该疗法既有非免疫机制作用也有免疫机制参与。
This article discusses the therapeutic effect and mechanism of intratumoral injection of DNCB solution on transplanted tumors in mice. The results showed that the intratumoral injection of DNCB solution had obvious curative effect on Ehrlich’s solid tumor in Kunming mice, which can effectively inhibit tumor growth, shrink the tumor size until complete regression, prolong lifespan of mice, and make mice resistant to tumors. Systemic immunity that is vaccinated again. The results of histopathological study showed that intratumoral injection of CNCB solution can not only directly cause necrosis of tumor tissue, but also produce lymphocyte infiltration characteristic of the cellular immune response locally in the tumor, indicating that the therapy has both non-immune mechanism and immune mechanism. participate.