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[目的]探讨宫颈鳞癌血清鳞癌相关抗原(SCC-Ag)值与临床病理参数之间的关系。[方法]回顾性分析204例ⅠB1￣ⅡA期宫颈鳞癌患者的血清SCC-Ag水平,应用χ2检验验证SCC-Ag值与患者临床病理参数之间的关系。[结果]宫颈鳞癌ⅠB2期患者的SCC-Ag高于ⅠB1和ⅡA期患者(P<0.001),随着肿瘤体积的增大(P<0.001)、淋巴结转移(P<0.001)和肌层受侵深度的加深(P<0.001),血清SCC-Ag值逐步升高;肿瘤分化高的患者SCC-Ag值也相应升高,但无统计学差异(P>0.05)。[结论]SCC-Ag是宫颈癌的重要临床肿瘤标志物,较高的血清SCC-Ag值可能意味着大的肿瘤体积、淋巴结转移以及深肌层受侵。
[Objective] To investigate the relationship between the value of SCC-Ag in cervical squamous cell carcinoma and clinicopathological parameters. [Methods] The serum level of SCC-Ag in 204 cases of stage ⅠB1ⅡA cervical squamous cell carcinoma was retrospectively analyzed. The relationship between the SCC-Ag value and the clinicopathological parameters was verified byχ2 test. [Results] The SCC-Ag in stage ⅠB2 cervical cancer was significantly higher than that in stage ⅠB1 and ⅡA (P <0.001). With the increase of tumor volume (P <0.001), lymph node metastasis (P <0.001) (P <0.001). The SCC-Ag value of serum increased gradually. The SCC-Ag value of patients with high tumor differentiation increased correspondingly, but there was no significant difference (P> 0.05). [Conclusion] SCC-Ag is an important clinical tumor marker of cervical cancer. The higher serum SCC-Ag value may mean large tumor volume, lymph node metastasis and invasion of deep myometrium.