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目的本文比较２２例中国南方汉人典型骨肉瘤患者与２５０例健康中国南方汉人的ＨＬＡ┐Ａ、┐Ｂ、┐ＤＲ、┐ＤＱ各位点抗原出现频率。方法测定７个ＨＬＡ┐Ａ，１７个ＨＬＡ┐Ｂ，１０个ＨＬＡ┐ＤＲ，三个ＨＬＡ┐ＤＱ抗原分型。结果病例组ＨＬＡ┐Ｂ３５位点抗原出现频率为０．３１８，正常对照组为０．０４８，统计结果显示含ＨＬＡ┐Ｂ３５位点抗原的中国南方汉人骨肉瘤发病的相对危险率是无此位点抗原者的９．２３２倍，校正Ｐ值为３．５３６×１０－３（Ｐ＜０．０１）。结论ＨＬＡ┐Ｂ３５位点抗原可能联锁着中国南方汉人骨肉瘤发病的易感性基因。
Objective To compare the frequency of antigens in HLA-A, ┐B, ┐DR, and ┐DQ sites of 22 cases of typical osteosarcoma in Han Chinese and 250 cases of healthy Chinese Han in southern China. Methods Seven HLA-A, 17 HLA-B, 10 HLA-DR and three HLA-DQ antigen types were determined. Results The frequency of HLA-B35 locus antigen was 0.318 in the case group and 0.048 in the normal control group. The statistical results showed that the relative risk of osteosarcoma in Han Chinese with HLA-B35 locus antigen was not found in this case. 9.232 times the antigen, corrected P value was 3.536×10-3 (P<0.01). Conclusion The HLA-B35 locus antigen may be associated with the susceptibility gene of osteosarcoma in Chinese Han population.