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目的:观察罗扰素水剂治疗慢性乙型和丙型肝炎的疗效。方法:常规治疗组以罗扰素水剂3×10~6,隔日1次,持续3个月;调整治疗组以罗扰素水剂4.5×10~6U,隔日1次,持续3～6个月;于治疗前、中、结束时及结束后3～6个月时检测HCV、HBV感染标志物及肝功能,并定量检测HCV-RNA、HBV-DN八及干扰素抗体。结果:常规治疗组HCV-RNA转阴率为50％,HBeAg和HBV-DNA转阴率为46.2％,完全反应者HCV-RNA和HBV-DNA拷贝数低于无反应者,干扰素抗体产生率也较低。结论:常规治疗后HCV-RNA、HBV-DNA、HDeAg阴转率以及ALT复常率与罗扰素粉剂相近,其疗效与病毒血症水平密切相关。
Objective: To observe the curative effect of lohexin aqueous solution on chronic hepatitis B and Methods: The conventional treatment group was treated with Luozuo Lotion 3 × 10 ~ 6, every other day for 3 months. The treatment group was treated with Luozuo Lotion 4.5 × 10 ~ 6U every other day for 3 ~ 6 months Month; HCV, HBV infection markers and liver function were detected before, during, at the end of the treatment and 3 to 6 months after the end of treatment, and HCV-RNA, HBV-DN and interferon antibodies were detected quantitatively. Results: In the conventional treatment group, the negative rate of HCV-RNA was 50%, the negative rate of HBeAg and HBV-DNA was 46.2%, the number of HCV-RNA and HBV-DNA in the complete response was lower than that in the non-responders, and the interferon antibody production rate Also lower. CONCLUSION: The negative conversion rates of HCV-RNA, HBV-DNA, HDeAg and ALT normalization rate after routine treatment are similar to those of lorazone powder. The curative effect is closely related to the level of viremia.