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目的 探讨干扰素联合肝动脉栓塞化疗预防肝细胞癌根治性切除术后复发的临床价值。方法 10例肝细胞癌患者于根治性切除术后2～8周经肝动脉导管行栓塞化疗。化疗后皮下注射重组α干扰素2a(罗扰素),第1～4周自100万单位渐增至450万单位维持12周。每周3次,4～6周后重复栓塞化疗一次。结果 9例患者随访超过1年,1例9个月,所有患者均未见肝内复发。结论 罗扰素可能有助于减少肝癌根治性切除术后肝内复发。
Objective To investigate the clinical value of interferon combined with hepatic artery embolization chemotherapy in preventing the recurrence of hepatocellular carcinoma after radical resection. Methods Ten patients with hepatocellular carcinoma underwent embolization with hepatic artery catheterization 2 to 8 weeks after radical resection. Subcutaneous injections of recombinant interferon 2a (prolinin) following chemotherapy were gradually increased from 1 million units to 4.5 million units in 1 to 4 weeks for 12 weeks. Three times a week, embolization chemotherapy was repeated 4 to 6 weeks later. Results Nine patients were followed up for more than 1 year and 1 patient was 9 months. None of the patients had intrahepatic recurrence. Conclusions Interferon may help to reduce intrahepatic recurrence after radical resection of hepatocellular carcinoma.