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光敏诊治恶性肿瘤,目前临床上普遍使用的光敏剂是血卟啉衍生物(HPD),但它滞留于皮肤中的量较多,排出缓慢,患者容易产生皮肤光毒反应。1985年Ben-Hur等在中国仑鼠细胞实验中表明氯铝酞菁是一种有效的哺乳动物细胞光敏剂,并指出已有二种酞菁衍生物(铜酞菁和铀酸基酞菁)被选作小鼠脑瘤定位之用。国内蔡怀新等人于1988年研制出新光敏剂磺化铝酞菁,并对具光敏特性及其对人体肝癌细胞的杀伤作用做了实验研究。本文为进一步研究磺化铝酞菁对癌的光敏诊断价值,用磺化铝酞菁对615近交系小鼠移植瘤——乳腺癌(Ca761)
Photosensitive diagnosis and treatment of malignant tumors, the current clinically widely used photosensitizer is hematoporphyrin derivative (HPD), but it is retained in the skin in a large amount, slow discharge, the patient is prone to skin phototoxic reaction. In 1985, Ben-Hur et al. showed that chloroaluminum phthalocyanine is an effective mammalian cell photosensitizer in Chinese ham cell experiments, and pointed out that there are two kinds of phthalocyanine derivatives (copper phthalocyanine and uranyl phthalocyanine). Selected for use as a mouse brain tumor. Domestic Cai Huaixin et al. developed a new photosensitizer sulfonated aluminum phthalocyanine in 1988, and conducted an experimental study on photosensitizing properties and its killing effect on human hepatoma cells. In this paper, in order to further study the photosensitive diagnostic value of sulfonated aluminum phthalocyanine for cancer, a luminized aluminum phthalocyanine pair 615 inbred mouse transplanted tumor-breast cancer (Ca761)