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目的 :观察非那雄胺对增生前列腺中微血管和增殖能力的影响。方法 :89例中、重度前列腺增生症手术病人分为 2组。非那雄胺组 4 3例 ,年龄(71±s12 )a ,用非那雄胺 5mg ,po ,qd ,术前服用 5～ 7d ;对照组 4 6例 ,不用药并用免疫组化S P法 ,对 2组术后前列腺组织标本进行CD3 4和PCNA的检测。结果 :非那雄胺组术中输血 6例 (14 % ) ,输血量 (2 8± 9)mL、术后继发性血尿 5例 (12 % ) ;对照组分别为 15例 (33% ) ,(87± 19)mL ,18例(39% ) ,(P <0 .0 5 )。 2组免疫组化血管数、血管内面积、血管壁面积分别为 (66.0± 1.9)条 ,(15 2 .3±1.8)cm2 ,(14 3.5± 1.9)cm2 和 (12 7.0± 2 .3)条 ,(338.8± 2 .3)cm2 ,(4 4 2 .5± 2 .3)cm2 (均P <0 .0 1)。其PCNA阳性表达分别为 2 3± 3和 4 7± 3(P <0 .0 1)。结论 :非那雄胺可通过抑制前列腺组织增殖和微血管形成 ,防止和减少术中及术后出血
Objective: To observe the effect of finasteride on proliferation of microvessels and proliferation in the prostatic hyperplasia. Methods: 89 cases of moderate and severe surgical benign prostatic hyperplasia patients were divided into two groups. Finasteride group 43 cases, age (71 ± s12) a, finasteride 5mg, po, qd, preoperative taking 5 ~ 7d; control group, 46 cases without medication and immunohistochemical SP method, Prostate tissue specimens from two groups were tested for CD34 and PCNA. Results: Blood transfusions were found in 6 cases (14%), blood transfusion (28 ± 9) mL and postoperative hematuria in 5 cases (12%) in the finasteride group and 15 cases (33%) in the control group , (87 ± 19) mL, 18 cases (39%), (P <0.05). The numbers of blood vessels, intravascular area and vessel wall area in the two groups were (66.0 ± 1.9), (15.2 ± 1.8) cm2, (14 3.5 ± 1.9) cm2 and (12 7.0 ± 2.3) (338.8 ± 2 .3) cm2, (4 4 2 .5 ± 2 .3) cm2 (all P <0.01). The positive expression of PCNA was 23 ± 3 and 47 ± 3 (P <0.01). Conclusion: Finasteride can prevent and reduce intraoperative and postoperative bleeding by inhibiting prostatic tissue proliferation and microvascular formation