论文部分内容阅读
1990—热带病控制年。首批人疟疾疫苗用于临床。纽约大学生产的疫苗是由疟原虫细胞表面基因克隆蛋白制成的。它能有效预防4种人疟疾。这是Omni杂志的编者1985年的预言。如今疟疾疫苗的效果与当年预期的相距甚远,原因是疟原虫的生活史复杂,出现显著的免疫的变异性,致使疫苗方案在近几年中明显受挫。疟疾疫苗的研究中有3个引人注目的靶子:子孢子、裂殖子和配子体。以照射的子孢子疫苗经对鸡、小鼠和人试验得到相似的结
1990 - Tropical Diseases Control Year. The first batch of malaria vaccine for clinical use. The vaccine produced by New York University is made of cloned protein from the surface of malaria parasite cells. It can effectively prevent 4 kinds of human malaria. This is the 1985 prophecy of the editors of Omni magazine. The effect of the malaria vaccine is now far from what was expected in the current year due to the complex life history of the malaria parasite and the significant immunological variability that has led to a significant setback in the vaccine program in recent years. There are three compelling targets in malaria vaccine research: sporozoites, merozoites and gametophytes. Similar shoots were obtained with irradiated sporozoite vaccines tested on chickens, mice and humans