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生物学因素一、遗传因素(一)染色体畸变随着遗传咨询和产前检查工作的开展,高龄产妇和近亲婚配的减少,染色体畸变儿童的出生数有所下降,但由于该因素较围产期及产后等因素难控制,故下降的幅度并不大,至今仍是重度MR最主要的致病因素。发达国家由于已较有效地控制了围产期及产后因素,如感染性疾病、营养不良及高危儿的抢救等,因此在MR的致病因素中,染色体畸变尤为突出,所致的MR数约占重度MR数的35%。
Biological factors First, genetic factors (A) Chromosomal aberrations With genetic counseling and prenatal care work carried out, the reduction of older mothers and their cousins, chromosome aberration in children decreased the number of births, but because of this factor than the perinatal And postpartum and other factors difficult to control, so the decline is not large, is still the main cause of severe MR risk factors. In developed countries, because of the more effective control of perinatal and postpartum factors such as infectious diseases, malnutrition and rescue of high-risk children, chromosomal aberrations are particularly prominent in the pathogenesis of MR. Accounting for 35% of severe MR number.