应用斑蝥治疗肿瘤在我国有着悠久的历史。在此基础上,近年来发展了一组斑蝥素衍生物的新抗癌药物,斑蝥酸钠(Disodium Cantharidate,以下简称“斑钠”)即属其中之一。临床资料表明,斑钠对肝癌、食道癌等恶性肿瘤有一定疗效,而无明显抑制造血功能等不良副作用。关于斑钠抗癌作用的机理,目前尚很少报道。本实 The use of spotting to treat cancer has a long history in China. On this basis, in recent years, a new anti-cancer drug of cantharidin derivatives has been developed. Disodium Cantharidate (hereinafter referred to as “spot sodium”) is one of them. Clinical data show that spotted sodium has a certain effect on liver cancer, esophageal cancer and other malignant tumors, but no significant inhibition of adverse effects such as hematopoietic function. The mechanism of the anti-cancer effect of spotted sodium is rarely reported. The real