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目的结合临床病理学特征探讨Survivin在子宫内膜癌组织中的表达。方法应用免疫组化SP法检测60例子宫内膜癌、33例癌旁组织和20例正常子宫内膜标本中Survivin蛋白的表达情况。结果Survivin蛋白在内膜癌组的阳性表达率为66.7%,显著高于正常内膜组10.0%及癌旁组织组9.1%(P<0.001)。Survivin在内膜癌组过表达率(++~+++)为55%,显著高于正常内膜组0%及癌旁组织组0%(P<0.001)。Survivin在临床晚期(Ⅲ~Ⅳ期)、组织学低分化(G2~G3级)、深肌层浸润(>1/2)及发生淋巴结转移的组织标本中的阳性表达率高于临床早期(I~Ⅱ期)、组织学分化好(G1级)、肌层浸润浅(≤1/2)及未发生淋巴结转移组(P<0.05)。结论Sur-vivin在子宫内膜癌中表达增高且多为中等及强阳性表达。对Survivin在子宫内膜癌中表达的检侧有助于子宫内膜癌的诊断、治疗及预后判断。
Objective To investigate the expression of Survivin in endometrial carcinoma with clinicopathological features. Methods Immunohistochemical SP method was used to detect the expression of Survivin protein in 60 cases of endometrial carcinoma, 33 cases of paracancerous tissues and 20 cases of normal endometrium. Results The positive expression rate of Survivin protein in endometrial carcinoma was 66.7%, which was significantly higher than that in normal endometrium group (10.0%) and paracancerous tissue group (9.1%, P <0.001). The overexpression rate of Survivin in endometrial carcinoma (++ ~ +++) was 55%, which was significantly higher than that in normal endometrium and 0% of paracancerous tissues (P <0.001). The positive rates of Survivin in clinical stage (stage Ⅲ ~ Ⅳ), histological poor differentiation (G2 ~ G3), deep myometrial invasion (> 1/2) and lymph node metastasis were higher than those in clinical stage ~ Ⅱ stage), histological differentiation (G1 stage), shallow myometrial invasion (≤1 / 2) and no lymph node metastasis (P <0.05). Conclusion Sur-vivin is highly expressed in endometrial carcinoma and mostly has moderate and strong positive expression. Detection of Survivin expression in endometrial cancer helps endometrial cancer diagnosis, treatment and prognosis.