目的:探讨重度产后出血的原因、相关因素、预防和处理措施。方法:回顾性分析2006年1月～2010年12月武汉市妇幼保健院发生的重度产后出血58例的临床资料。结果:武汉市妇幼保健院重度产后出血发生率为0.368%,出血原因按发生率高低依次为宫缩乏力、胎盘因素、凝血机制障碍、妊娠合并子宫肌瘤。结论:产前做好高危因素的筛选,预防产后出血的发生;正确处理产程,积极治疗宫缩乏力,正确处理前置胎盘,及时采取适宜的抢救措施,是重度产后出血抢救成功的关键。 Objective: To explore the causes of severe postpartum hemorrhage, related factors, prevention and treatment measures. Methods: The clinical data of 58 cases of severe postpartum hemorrhage in Wuhan MCH hospital from January 2006 to December 2010 were retrospectively analyzed. Results: The incidence of severe postpartum hemorrhage was 0.368% in Wuhan Maternal and Child Health Hospital. The causes of bleeding were as follows: uterine atony, placenta, coagulopathy, and uterine fibroids in pregnancy. Conclusion: Prenatal screening of high risk factors to prevent postpartum hemorrhage; correct treatment of labor, active treatment of uterine inertia, correct placenta previa, timely and appropriate rescue measures is the key to the success of severe postpartum hemorrhage.