恶性嗜铬细胞瘤临床中较罕见 ,由于缺乏早期特异性的诊断标准 ,给临床诊治带来较大困难。近年来 ,随着肿瘤分子生物学研究深入和影像学技术的进步 ,恶性嗜铬细胞瘤的诊断方法有了较大发展 ,现从组织病理学、影像学、肿瘤标记物等方面对恶性嗜铬细胞瘤诊断进展作一综述 Malignant pheochromocytoma rare in clinical, due to the lack of early diagnosis of specific criteria to clinical diagnosis and treatment more difficult. In recent years, with the in-depth study of tumor molecular biology and imaging technology advances, the diagnosis of malignant pheochromocytoma has been a great development, now from histopathology, imaging, tumor markers and other aspects of malignant chromaffin The progress of diagnosis of cell tumor is reviewed