论文部分内容阅读
目的观察糖尿病微血管并发症患者糖化血红蛋白(Hb A1c)及凝血功能的改变,探讨其水平变化及意义。方法检测2型糖尿病合并微血管病变者、糖尿病未合并微血管病变者及正常人的空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)和凝血酶时间(TT)水平,并比较差异。结果与正常对照组相比,糖尿病合并微血管病变组、糖尿病未合并微血管病变组FPG、Hb A1c、FIB水平升高,PT、APTT水平降低,差异有统计学意义(P<0.05)。糖尿病合并微血管病变组TT水平较正常对照组升高,差异有统计学意义(P<0.05)。与糖尿病未合并微血管病变组相比,糖尿病合并微血管病变组FPG、Hb A1c、FIB水平升高,APTT水平较低,差异有统计学意义(P<0.01)。FPG与Hb A1c水平呈正相关(r=0.273,P<0.05),Hb A1c与FIB水平呈正相关(r=0.250,P<0.05)。结论糖尿病患者Hb A1c、PT、APTT、FIB及TT水平检测对2型糖尿病患者合并血管并发症的早期诊断及了解病情进展有重要临床意义。
Objective To observe the changes of HbA1c and coagulation function in patients with diabetic microvascular complications and to explore the changes and significance of HbA1c levels. Methods Fasting blood glucose (FPG), HbA1c, PT, APTT and blood pressure were measured in patients with type 2 diabetes mellitus and microangiopathy, those without diabetes mellitus and microvascular disease, , Fibrinogen (FIB) and thrombin time (TT) levels, and compare differences. Results Compared with the normal control group, the levels of FPG, Hb A1c, FIB and the levels of PT and APTT in patients with diabetes mellitus and microangiopathy without diabetes mellitus were significantly decreased (P <0.05). Compared with normal control group, the TT level in diabetic patients with microangiopathy was significantly higher (P <0.05). The levels of FPG, Hb A1c, FIB and APTT were lower in patients with diabetes mellitus and microangiopathy than in those without diabetes mellitus. The difference was statistically significant (P <0.01). There was a positive correlation between FPG and Hb A1c levels (r = 0.273, P <0.05). There was a positive correlation between Hb A1c and FIB levels (r = 0.250, P <0.05). Conclusion The detection of Hb A1c, PT, APTT, FIB and TT in patients with diabetes mellitus has an important clinical significance in the early diagnosis of type 2 diabetes mellitus complicated with vascular complications and the understanding of the progression of the disease.