论文部分内容阅读
目的探讨左卡尼汀对冠心病不稳定型心绞痛患者血清高敏C-反应蛋白(hs-CRP)和脑型钠尿肽(BNP)的水平的影响,了解左卡尼汀对心绞痛的治疗作用。方法入选106例冠状动脉造影阳性心绞痛患者,按病情分为稳定性和不稳定性心绞痛两大组,每一组再随机分为两组,治疗组和对照组,测定各组患者hs-CRP、BNP的水平和左心室射血分数(LVEF)。治疗组和对照组在冠状动脉病变程度、hs-CRP、BNP的水平和左心室射血分数(LVEF)无差异。两组均按照常规给予阿司匹林肠溶片、他汀类药物、低分子肝素、硝酸酯类药物、β-受体阻滞剂等基础治疗,治疗组给予左卡尼汀2.0g入液静脉滴注,1次/d,对照组给予黄芪注射液40ml入液静脉滴注1次/d。结果所有患者在治疗后,hs-CRP和BNP均有明显下降,LVEF有明显升高,其中治疗1组比对照1组,hs-CRP和BNP下降更显著,LVEF显著升高,有统计学差异;同样治疗2组也取得上述结果。结论左卡尼汀能够明显减低心绞痛患者的血hs-CRP和BNP水平,提高LVEF,缓解心绞痛、改善心功能。
Objective To investigate the effects of levocarnitine on the serum levels of hs-CRP and BNP in patients with coronary heart disease and to understand the therapeutic effect of levocarnitine on angina pectoris. Methods 106 cases of coronary angiography positive angina patients were divided into two groups according to the disease: stable and unstable angina, each group were randomly divided into two groups, the treatment group and the control group, the hs-CRP, BNP levels and left ventricular ejection fraction (LVEF). There was no difference in the severity of coronary artery disease, hs-CRP, BNP and left ventricular ejection fraction (LVEF) between the treatment group and the control group. Both groups were given routine treatment with aspirin enteric-coated tablets, statins, low molecular weight heparin, nitrates, β-blockers and other basic treatment, the treatment group was given intravenous infusion of levocarnitine 2.0g, 1 times / d, the control group given Astragalus injection 40ml intravenous drip 1 / d. Results After treatment, hs-CRP and BNP were significantly decreased in all patients, and LVEF was significantly increased. The treatment group 1 than the control group 1, hs-CRP and BNP decreased more significantly, LVEF increased significantly, with statistical difference The same treatment of two groups also made the above results. Conclusion L-carnitine can obviously reduce the blood levels of hs-CRP and BNP in patients with angina, improve LVEF, relieve angina and improve heart function.