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子宫内膜癌是最常见的妇科恶性肿瘤之一,其发生是一个多步骤的过程,伴随着许多分子生物学的改变。越来越多的实验表明,在肿瘤的发生和发展中存在DNA甲基化水平和模式的混乱,包括基因组总体甲基化水平过低和某些基因启动子区域甲基化过高。DNA甲基化异常可通过影响染色质结构以及癌基因和抑癌基因表达而参与肿瘤的形成。现已在肿瘤的细胞周期调节基因、DNA错配修复基因、肿瘤抑制基因等多种基因中发现甲基化现象。了解目前对子宫内膜癌中DNA甲基化的研究进展有助于子宫内膜癌的早期发现和早期治疗,并改善预后。
Endometrial cancer is one of the most common gynecological malignancies and its occurrence is a multi-step process accompanied by many molecular biological changes. More and more experiments show that in the occurrence and development of tumors, DNA methylation level and pattern of confusion exist, including the overall genome methylation level is too low and some gene promoter hypermethylation. Aberrant DNA methylation can participate in tumor formation by affecting the chromatin structure and the expression of oncogenes and tumor suppressor genes. Now in the tumor cell cycle regulatory genes, DNA mismatch repair genes, tumor suppressor genes found in a variety of genes such as methylation. Understanding of the current research on DNA methylation in endometrial cancer will help early detection and early treatment of endometrial cancer and improve prognosis.